Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876383 | 0.99 | HTR1A (0.69) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875343 | 0.95 | HTR1A (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8875603 | 0.94 | HTR1A (0.68) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876618 | 0.89 | HTR1A (0.69) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8874490 | 0.88 | HTR1A (0.66) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8874175 | 0.88 | HTR1A (0.69) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876415 | 0.88 | HTR1A (0.70) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL8876154 | 0.88 | ADRA1A (0.73) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8875614 | 0.87 | HTR1A (0.65) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL8875342 | 0.87 | HTR1A (0.69) | HTR1AADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |