Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 4/20 | 0.33 |
| ▸ | HMGCR | P04035 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876833 | 0.92 | HMGCR (0.33) | CTSAHMGCRDHODH | |
| SCHEMBL8877078 | 0.90 | HMGCR (0.39) | HMGCR | |
| SCHEMBL8902033 | 0.85 | HMGCR (0.34) | CTSAHMGCRDHODH | |
| SCHEMBL8899819 | 0.84 | HMGCR (0.32) | CTSAHMGCRDHODH | |
| SCHEMBL8877505 | 0.82 | HMGCR (0.40) | HMGCR | |
| SCHEMBL8877642 | 0.80 | HMGCR (0.35) | CTSAHMGCRDHODH | |
| SCHEMBL8878253 | 0.79 | HMGCR (0.33) | CTSAHMGCRDHODH | |
| SCHEMBL8878710 | 0.78 | HMGCR (0.39) | HMGCR | |
| SCHEMBL8878763 | 0.77 | HMGCR (0.38) | HMGCR | |
| SCHEMBL8876157 | 0.77 | HMGCR (0.36) | CTSAHMGCRDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |