Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875618 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2ASMPD1ALDH1A1 | |
| SCHEMBL8874498 | 0.96 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ASMPD1ALDH1A1 | |
| SCHEMBL8874879 | 0.93 | MEN1 (0.46) | MEN1KMT2ASMPD1PPARG | |
| SCHEMBL8915786 | 0.89 | EGLN1 (0.42) | SMPD1PTPN1GABRA5 | |
| SCHEMBL8915832 | 0.89 | EGLN1 (0.42) | SMPD1PTPN1GABRA5 | |
| SCHEMBL8105616 | 0.87 | PPARG (0.40) | SMN1; SMN2MEN1KMT2ASMPD1PPARG | |
| SCHEMBL8099518 | 0.87 | PPARG (0.40) | SMN1; SMN2MEN1KMT2ASMPD1PPARG | |
| SCHEMBL8915506 | 0.85 | EGLN1 (0.43) | SMPD1GABRA5 | |
| SCHEMBL8874924 | 0.85 | SMPD1 (0.44) | SMPD1PTPN1PPARGGABRA5 | |
| SCHEMBL8875849 | 0.85 | SMPD1 (0.44) | SMPD1PTPN1PPARGGABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620996-A | Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |
| US-5610172-A | Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-11 | — | — | US | disclosed |