Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.41 |
| ▸ | HMGCR | P04035 | 5/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876861 | 0.87 | GCGR (0.46) | GCGRHMGCR | |
| SCHEMBL8878730 | 0.85 | HMGCR (0.42) | GCGRHMGCRPTGS2 | |
| SCHEMBL8876495 | 0.84 | HMGCR (0.54) | GCGRHMGCR | |
| SCHEMBL8952722 | 0.83 | HMGCR (0.41) | GCGRHMGCR | |
| SCHEMBL8877967 | 0.80 | HMGCR (0.52) | GCGRHMGCR | |
| SCHEMBL8877450 | 0.79 | GCGR (0.50) | GCGRHMGCR | |
| SCHEMBL8878764 | 0.79 | HMGCR (0.44) | GCGRHMGCR | |
| SCHEMBL8952718 | 0.78 | HMGCR (0.43) | GCGRHMGCRPTGDR2 | |
| SCHEMBL8877751 | 0.78 | DHODH (0.42) | GCGRPTGDR2 | |
| SCHEMBL8876862 | 0.78 | HMGCR (0.42) | GCGRHMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |