Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.54 |
| ▸ | GCGR | P47871 | 3/20 | 0.43 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878764 | 0.87 | HMGCR (0.44) | HMGCRGCGR | |
| SCHEMBL8875477 | 0.86 | HMGCR (0.42) | HMGCRGCGR | |
| SCHEMBL8876862 | 0.86 | HMGCR (0.42) | HMGCRGCGRSQOR | |
| SCHEMBL8877967 | 0.86 | HMGCR (0.52) | HMGCRGCGR | |
| SCHEMBL8877998 | 0.84 | HMGCR (0.43) | HMGCRGCGR | |
| SCHEMBL8876345 | 0.84 | GCGR (0.41) | HMGCRGCGR | |
| SCHEMBL8876861 | 0.84 | GCGR (0.46) | HMGCRGCGR | |
| SCHEMBL8878341 | 0.84 | HMGCR (0.57) | HMGCRSQORTOP1ADORA2AADORA1 | |
| SCHEMBL8225619 | 0.84 | HMGCR (0.54) | HMGCRGCGRSQORTOP1ADORA2A | |
| SCHEMBL8846077 | 0.84 | HMGCR (0.54) | HMGCRGCGRSQORTOP1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0361273-B1 | 7-Substituted derivatives of 3,5-dihydroxyhept-6-inoic acid, process for their preparation, their use as medicaments, and intermediates | HOECHST AG (DE) | 1994-03-23 | — | — | EP | disclosed |
| US-5091386-A | Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| EP-0361273-A2 | 7-Substituted derivatives of 3,5-dihydroxyhept-6-inoic acid, process for their preparation, their use as medicaments, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-04-04 | — | — | EP | disclosed |
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |