Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.42 |
| ▸ | GCGR | P47871 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877661 | 0.86 | GCGR (0.46) | HMGCRGCGR | |
| SCHEMBL8876345 | 0.85 | GCGR (0.41) | HMGCRGCGRPTGS2 | |
| SCHEMBL8878341 | 0.83 | HMGCR (0.57) | HMGCR | |
| SCHEMBL8877751 | 0.81 | DHODH (0.42) | GCGR | |
| SCHEMBL8877450 | 0.80 | GCGR (0.50) | HMGCRGCGR | |
| SCHEMBL8878416 | 0.79 | SQOR (0.39) | — | |
| SCHEMBL6961433 | 0.78 | HMGCR (0.54) | HMGCRGCGR | |
| SCHEMBL8876796 | 0.77 | HMGCR (0.46) | HMGCRGCGR | |
| SCHEMBL8877432 | 0.76 | HMGCR (0.44) | HMGCRGCGR | |
| SCHEMBL8878217 | 0.75 | HMGCR (0.57) | HMGCRGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |