Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 8/20 | 0.75 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.75 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.75 |
| ▸ | HTR1A | P08908 | 7/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27348716 | 0.99 | ADRA1A (0.74) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| SCHEMBL8875934 | 0.97 | HTR1A (0.71) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8875713 | 0.96 | HTR1A (0.69) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8875715 | 0.96 | HTR1A (0.69) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| SCHEMBL8877818 | 0.95 | HTR1A (0.69) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8875648 | 0.94 | HTR1A (0.69) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| SCHEMBL8875435 | 0.87 | HTR1A (0.71) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| SCHEMBL8876154 | 0.87 | ADRA1A (0.73) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| SCHEMBL8876505 | 0.86 | HTR1A (0.71) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8876536 | 0.86 | ADRA1A (0.72) | ADRA1AADRA1DADRA1BHTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040434-C | Heterobicyclic compounds | RECORDATI CHEM PHARM (CH) | 1998-10-28 | — | — | CN | claimed |
| US-5605896-A | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1997-02-25 | — | — | US | claimed |
| US-5403842-A | Adrenergic blocking and antiserotonine agents; urogenital disorders including spasms of the urethral tract and prostrate problems | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-04-04 | — | — | US | claimed |
| EP-0558245-A1 | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1993-09-01 | — | — | EP | claimed |