Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877170 | 0.85 | MME (0.40) | PDPK1MMEALDH1A1KDM4EFFAR1 | |
| SCHEMBL8878251 | 0.85 | LMNA (0.37) | PDPK1MMEALDH1A1KDM4EFFAR1 | |
| SCHEMBL8878618 | 0.81 | PDPK1 (0.51) | PDPK1ALDH1A1KDM4EHTTNPC1 | |
| SCHEMBL8877845 | 0.79 | TDP1 (0.41) | PDPK1ALDH1A1KDM4EHTTNPC1 | |
| SCHEMBL8876896 | 0.76 | PDPK1 (0.41) | PDPK1ALDH1A1KDM4ENPC1 | |
| SCHEMBL8878459 | 0.73 | PDPK1 (0.40) | PDPK1ALDH1A1KDM4EHTTMAPK1 | |
| SCHEMBL2139054 | 0.70 | PDPK1 (0.62) | PDPK1NPC1 | |
| SCHEMBL9655539 | 0.69 | NPC1 (0.41) | ALDH1A1KDM4EHTTNPC1LMNA | |
| SCHEMBL2142907 | 0.68 | PDPK1 (0.63) | PDPK1ALDH1A1LMNA | |
| SCHEMBL28049454 | 0.68 | FFAR1 (0.36) | ALDH1A1FFAR1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |