Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877170 | 0.88 | MME (0.40) | NPC1PDPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL8878618 | 0.84 | PDPK1 (0.51) | TDP1NPC1PDPK1ALDH1A1KDM4E | |
| SCHEMBL8878251 | 0.82 | LMNA (0.37) | NPC1PDPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL8876896 | 0.79 | PDPK1 (0.41) | TDP1NPC1PDPK1ALDH1A1KDM4E | |
| SCHEMBL8876550 | 0.79 | PDPK1 (0.36) | NPC1PDPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL8878459 | 0.76 | PDPK1 (0.40) | TDP1PDPK1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9857098 | 0.76 | PDPK1 (0.55) | PDPK1ALDH1A1CYP3A4CYP2D6KDM4E | |
| SCHEMBL917627 | 0.73 | NPC1 (0.48) | TDP1NPC1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9655539 | 0.73 | NPC1 (0.41) | TDP1NPC1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL2142907 | 0.72 | PDPK1 (0.63) | TDP1PDPK1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |