SCHEMBL8876609

SCHEMBL8876609

CCOC(=O)CCc1ccc(C#Cc2cc3c(cc2CC)SC(C)(C)CC3(C)C)nc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.41
RARA P10276 2/20 0.41
RARB P10826 2/20 0.41
RARG P13631 2/20 0.41
KMT2A Q03164 1/20 0.41
FFAR1 O14842 1/20 0.35
FFAR4 Q5NUL3 1/20 0.35
CYP4F2 P78329 1/20 0.35
CYP4A11 Q02928 1/20 0.35
ACACB O00763 1/20 0.35
JAK2 O60674 1/20 0.34
JAK1 P23458 1/20 0.34
TYK2 P29597 1/20 0.34
JAK3 P52333 1/20 0.34
FDFT1 P37268 1/20 0.33
CYP26A1 O43174 1/20 0.33
SYK P43405 3/20 0.32
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31
P2RY12 Q9H244 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8875500 0.94 CYP3A4 (0.40) CYP3A4RARARARBRARGKMT2A
SCHEMBL8875274 0.93 CYP3A4 (0.41) CYP3A4RARARARBRARGKMT2A
SCHEMBL8875128 0.87 CYP3A4 (0.40) CYP3A4RARARARBRARGKMT2A
SCHEMBL9282153 0.87 CYP4F2 (0.40) CYP3A4RARARARBRARGKMT2A
SCHEMBL6666798 0.86 RARA (0.55) CYP3A4RARARARBRARGKMT2A
SCHEMBL8865484 0.84 RARA (0.58) CYP3A4RARARARBRARGKMT2A
SCHEMBL8865217 0.84 CYP3A4 (0.37) CYP3A4RARARARBRARGKMT2A
SCHEMBL8875083 0.84 CYP26A1 (0.38) CYP3A4RARARARBRARGKMT2A
SCHEMBL8865411 0.83 CYP3A4 (0.35) CYP3A4RARARARBRARGKMT2A
SCHEMBL8865443 0.81 RARA (0.37) CYP3A4RARARARBRARGKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616597-A ANTIACNE, ANTIPSORIASIS COMPOUNDS ALLERGAN (US) 1997-04-01 US disclosed
US-5599819-A SKIN DISORDERS ALLERGAN 1997-02-04 US disclosed
US-5534516-A Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1, 2, 3, 4-tetrahydroquinolinyl group having retinoid-like activity ALLERGAN 1996-07-09 US disclosed
EP-0419130-B1 Acetylenes disubstituted with a heteroaromatic group and A 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity ALLERGAN INC (US) 1995-11-15 EP disclosed
US-5407937-A Skin disorders, skin cancer ALLERGAN, INC. (US) 1995-04-18 US disclosed
US-5272156-A Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity ALLERGAN, INC. (US) 1993-12-21 US disclosed
EP-0555235-A4 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY 1993-11-10 EP disclosed
EP-0555235-A1 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-18 EP disclosed
US-5183827-A Skin disorders ALLERGAN, INC. (US) 1993-02-02 US disclosed
WO-1992006092-A1 ACETYLENES DISUBSTITUTED WITH A HETEROAROMATIC GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-04-16 WO disclosed
US-5045551-A Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity ALLERGAN, INC. (US) 1991-09-03 US disclosed
EP-0419130-A2 Acetylenes disubstituted with a heteroaromatic group and A 2-substituted chromanyl, thiochromanyl or 1,2,3,4- tetrahydroquinolinyl group having retinoid-like activity ALLERGAN, INC. (US) 1991-03-27 EP disclosed