Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876138 | 0.92 | SQOR (0.35) | VCPKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL8878790 | 0.86 | HMGCR (0.38) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8877904 | 0.86 | KDM4E (0.37) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8876647 | 0.85 | HMGCR (0.37) | KDM4ELMNAHPGDNPSR1HMGCR | |
| SCHEMBL8877719 | 0.84 | PRKAA2 (0.35) | HMGCR | |
| SCHEMBL8877802 | 0.81 | HMGCR (0.39) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8877188 | 0.81 | HMGCR (0.42) | KDM4ELMNAHPGDNPSR1HMGCR | |
| SCHEMBL8877833 | 0.78 | HMGCR (0.32) | HMGCR | |
| SCHEMBL8877239 | 0.78 | HMGCR (0.31) | HMGCR | |
| SCHEMBL8878938 | 0.77 | HMGCR (0.33) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |