Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877685 | 0.91 | AKR1B1 (0.38) | AKR1B1KDM1AHSD11B1ALDH1A1DRD1 | |
| SCHEMBL8602565 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL8601315 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL8601902 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL9035567 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL8878875 | 0.84 | AKR1B1 (0.34) | AKR1B1HSD11B1DRD1 | |
| SCHEMBL8601899 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL9035580 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL8602566 | 0.84 | DRD1 (0.38) | AKR1B1HSD11B1ALDH1A1DRD1 | |
| SCHEMBL8877099 | 0.84 | ABL1 (0.37) | ALDH1A1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681840-A | ANTIDOPAMINERGIC AGENTS | ZENECA LIMITED (GB) | 1997-10-28 | — | — | US | disclosed |
| EP-0533344-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5512575-A | ANTISEROTONINE AGENT | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| EP-0533344-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |