Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035580 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL8601902 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL8601315 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL8878875 | 0.93 | AKR1B1 (0.34) | AKR1B1HSD11B1DRD1TSHRCA1 | |
| SCHEMBL8602565 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL9035567 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL8601899 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL8602566 | 0.93 | DRD1 (0.38) | AKR1B1HSD11B1DRD1ALDH1A1MEN1 | |
| SCHEMBL8876907 | 0.91 | AKR1B1 (0.34) | AKR1B1HSD11B1KDM1ADRD1ALDH1A1 | |
| SCHEMBL8875582 | 0.88 | CDYL (0.40) | ALDH1A1SMN1; SMN2TSHRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681840-A | ANTIDOPAMINERGIC AGENTS | ZENECA LIMITED (GB) | 1997-10-28 | — | — | US | disclosed |
| EP-0533344-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| US-5512575-A | ANTISEROTONINE AGENT | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| EP-0533344-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |