SCHEMBL8877154

SCHEMBL8877154

NC(=O)NS(=O)(=O)c1ccccc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
KDM4E B2RXH2 2/20 0.42
ACLY P53396 3/20 0.41
TDP1 Q9NUW8 1/20 0.41
PTGES O14684 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CA1 P00915 7/20 0.41
CA2 P00918 7/20 0.41
CA9 Q16790 6/20 0.41
CDK2 P24941 1/20 0.40
CA5A P35218 1/20 0.40
F2 P00734 1/20 0.39
PRSS1 P07477 1/20 0.39
PRSS2 P07478 1/20 0.39
PRSS3 P35030 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10474078 0.85 PTGES (0.55) MEN1KMT2APTGESCA1CA2
SCHEMBL10729804 0.81 CA1 (0.55) MEN1KMT2APTGESCA1CA2
SCHEMBL10667500 0.81 MEN1 (0.44) MEN1KMT2APTGESCA1CA2
SCHEMBL3069664 0.81 GAA (0.52) MEN1KMT2ATDP1CA1CA2
SCHEMBL2351670 0.79 POLB (0.56) MEN1KMT2AALDH1A1TSHRHSD17B10
SCHEMBL29543742 0.79 POLB (0.56) MEN1KMT2AALDH1A1TSHRHSD17B10
SCHEMBL29489599 0.79 MEN1 (0.55) MEN1KMT2AALDH1A1HPGDTSHR
SCHEMBL16739378 0.79 MEN1 (0.55) MEN1KMT2AALDH1A1HPGDTSHR
SCHEMBL6465947 0.79 CA1 (0.55) MEN1KMT2AKDM4ETDP1ALDH1A1
SCHEMBL7924259 0.79 F2 (0.49) MEN1KMT2AKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0094790-A2 Herbicidal O-alkoxybenzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-11-23 EP claimed
US-5591694-A COMPOUND USED TO CONTROL UNDESIRABLE PLANT GROWTH BASF AKTIENGESELLSCHAFT (DE) 1997-01-07 US disclosed
US-4661146-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-04-28 US disclosed
US-4500344-A Herbicidal ortho-(alkoxy)-benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-02-19 US disclosed
US-4425153-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS & CO. (US) 1984-01-10 US disclosed