Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877856 | 0.91 | HMGCR (0.37) | HMGCRGCGRRXRAALDH1A1MAPT | |
| SCHEMBL8899571 | 0.88 | HMGCR (0.34) | HMGCRGCGR | |
| SCHEMBL8899623 | 0.88 | HMGCR (0.34) | HMGCRGCGR | |
| SCHEMBL8901358 | 0.87 | HMGCR (0.37) | HMGCRGCGR | |
| SCHEMBL8876699 | 0.85 | GCGR (0.37) | HMGCRGCGR | |
| SCHEMBL8875951 | 0.85 | HMGCR (0.53) | HMGCR | |
| SCHEMBL8878763 | 0.83 | HMGCR (0.38) | HMGCRGCGRRXRAALDH1A1MAPT | |
| SCHEMBL8879106 | 0.81 | PPARG (0.33) | — | |
| SCHEMBL8877788 | 0.81 | PRNP (0.32) | HMGCR | |
| SCHEMBL8908743 | 0.81 | HMGCR (0.32) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |