Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878699 | 0.92 | CCR2 (0.46) | CCR2HTR1AHTR2AHTR2CDRD3 | |
| SCHEMBL8875703 | 0.92 | CCR2 (0.46) | CCR2HTR1AHTR2AHTR2CDRD3 | |
| SCHEMBL8878052 | 0.90 | CCR2 (0.45) | CCR2HTR1AHTR2AHTR2CDRD3 | |
| SCHEMBL8877696 | 0.90 | PREP (0.47) | CCR2HTR1AHTR2AHTR2CDRD3 | |
| SCHEMBL8877860 | 0.88 | DRD2 (0.57) | CCR2HTR1AHTR2AHTR2CDRD3 | |
| SCHEMBL8879724 | 0.88 | CCR2 (0.56) | CCR2HTR1AHTR2ADRD2PREP | |
| SCHEMBL8877651 | 0.88 | CCR2 (0.50) | CCR2HTR1AHTR2AHTR2CDRD3 | |
| SCHEMBL8876587 | 0.87 | CCR2 (0.51) | CCR2HTR1AHTR2ADRD2PREP | |
| SCHEMBL8878073 | 0.87 | CCR2 (0.56) | CCR2HTR1AHTR2ADRD2ACHE | |
| SCHEMBL9035662 | 0.86 | CCR2 (0.48) | CCR2DRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |