Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902499 | 0.91 | SLC6A4 (0.30) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8878790 | 0.89 | HMGCR (0.38) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8876573 | 0.86 | VCP (0.35) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8877802 | 0.83 | HMGCR (0.39) | KDM4EALDH1A1LMNAHPGDNPSR1 | |
| SCHEMBL8876998 | 0.81 | HMGCR (0.38) | SQOR | |
| SCHEMBL8877833 | 0.80 | HMGCR (0.32) | — | |
| SCHEMBL8877239 | 0.80 | HMGCR (0.31) | — | |
| SCHEMBL8878938 | 0.79 | HMGCR (0.33) | — | |
| SCHEMBL8878253 | 0.79 | HMGCR (0.33) | HPGDKMT2A | |
| SCHEMBL8878313 | 0.79 | HMGCR (0.32) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |