Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | GCGR | P47871 | 3/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878010 | 1.00 | RXRA (0.44) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL9380517 | 0.85 | RXRA (0.47) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL8321756 | 0.85 | GCGR (0.46) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL22876085 | 0.85 | GCGR (0.58) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL9044031 | 0.84 | GCGR (0.47) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL9044036 | 0.84 | GCGR (0.47) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL22876086 | 0.82 | GCGR (0.67) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL8880602 | 0.81 | GCGR (0.52) | RXRAGCGRNR1I2NR4A2PDE4D | |
| SCHEMBL8878483 | 0.81 | GCGR (0.43) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL8878489 | 0.81 | GCGR (0.43) | GCGRHMGCRESR1CHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0356788-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1990-03-07 | — | — | EP | disclosed |