Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878483 | 1.00 | GCGR (0.43) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL8879706 | 0.85 | GCGR (0.44) | GCGRHMGCRDHODH | |
| SCHEMBL8879800 | 0.82 | GCGR (0.50) | GCGRHMGCRDHODH | |
| SCHEMBL9562749 | 0.81 | HMGCR (0.56) | GCGRHMGCR | |
| SCHEMBL8877995 | 0.81 | RXRA (0.44) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL9562755 | 0.81 | HMGCR (0.56) | GCGRHMGCR | |
| SCHEMBL8878010 | 0.81 | RXRA (0.44) | GCGRHMGCRESR1CHRM1TBXA2R | |
| SCHEMBL8878292 | 0.79 | RXRA (0.48) | HMGCRDHODH | |
| SCHEMBL8878297 | 0.79 | RXRA (0.48) | HMGCRDHODH | |
| SCHEMBL8952861 | 0.79 | HMGCR (0.67) | HMGCRESR1CHRM1TBXA2RPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |