Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876720 | 0.94 | HMGCR (0.59) | HMGCRADORA2AADORA1GCGR | |
| SCHEMBL8876495 | 0.83 | HMGCR (0.54) | HMGCRADORA2AADORA1GCGR | |
| SCHEMBL8876861 | 0.82 | GCGR (0.46) | HMGCRGCGR | |
| SCHEMBL8877967 | 0.82 | HMGCR (0.52) | HMGCRGCGR | |
| SCHEMBL8878764 | 0.81 | HMGCR (0.44) | HMGCRGCGRMAPT | |
| SCHEMBL8876862 | 0.80 | HMGCR (0.42) | HMGCRGCGR | |
| SCHEMBL8877873 | 0.79 | HMGCR (0.62) | HMGCRADORA2AADORA1GCGR | |
| SCHEMBL8876732 | 0.79 | GCGR (0.44) | HMGCRGCGR | |
| SCHEMBL8877601 | 0.79 | MAPT (0.42) | HMGCRGCGRKDM4EMAPTL3MBTL1 | |
| SCHEMBL8877870 | 0.79 | HMGCR (0.54) | HMGCRGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |