Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.65 |
| ▸ | GLA | P06280 | 2/20 | 0.65 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.55 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.55 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.55 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011365 | 0.85 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL7814727 | 0.85 | ABCC9 (0.60) | GAAABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL5227900 | 0.84 | MEN1 (0.53) | KDM4EALDH1A1HPGDGAAABCC9 | |
| SCHEMBL7833415 | 0.84 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDGAAABCC9 | |
| SCHEMBL6910323 | 0.83 | MEN1 (0.49) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL7835693 | 0.80 | ABCC9 (0.52) | KDM4EALDH1A1HPGDGAAABCC9 | |
| SCHEMBL7824821 | 0.79 | CACNA1F (0.58) | KDM4EALDH1A1HPGDGAAKMT2A | |
| SCHEMBL6928301 | 0.78 | ABCC9 (0.50) | KDM4EALDH1A1GAAABCC9ABCC8 | |
| SCHEMBL5061501 | 0.77 | FFAR3 (0.75) | KDM4E | |
| SCHEMBL7838163 | 0.77 | KMT2A (0.53) | KDM4EALDH1A1HPGDGAAABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622964-A | ADMINISTERING 4,6,7,8-TETRAHYDRO-5(1H)-QUINOLONE DERIVATIVE TO TREAT ASTHMA IN MAMMALS | ZENECA LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5455253-A | For urinary incontinence | ZENECA LIMITED (GB) | 1995-10-03 | — | — | US | disclosed |
| EP-0665834-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994008966-A1 | QUINOLONE AND ACRIDINONE DERIVATIVES FOR THE TREATMENT OF URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1994-04-28 | — | — | WO | disclosed |