Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8876825 | 0.83 | PPARA (0.46) | HMGCRGCGRDHODHMEN1NPC1 | |
| SCHEMBL8880943 | 0.83 | GCGR (0.45) | GCGRDHODHFABP3FABP4FABP5 | |
| SCHEMBL8879993 | 0.81 | HMGCR (0.49) | HMGCRSQORGCGRDHODHFABP3 | |
| SCHEMBL8878856 | 0.80 | GCGR (0.46) | HMGCRGCGRFABP3FABP4FABP5 | |
| SCHEMBL8879135 | 0.79 | GCGR (0.54) | HMGCRGCGR | |
| SCHEMBL8878217 | 0.78 | HMGCR (0.57) | HMGCRSQORGCGR | |
| SCHEMBL8878154 | 0.77 | DHODH (0.44) | HMGCRSQORGCGRDHODHFABP3 | |
| SCHEMBL8877751 | 0.77 | DHODH (0.42) | GCGRDHODHFABP3FABP4FABP5 | |
| SCHEMBL8875727 | 0.76 | HMGCR (0.57) | HMGCRSQORGCGR | |
| SCHEMBL8875731 | 0.76 | HMGCR (0.57) | HMGCRSQORGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |