Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877751 | 0.87 | DHODH (0.42) | GCGRFABP3FABP4FABP5DHODH | |
| SCHEMBL8876825 | 0.86 | PPARA (0.46) | GCGRFABP3FABP4FABP5DHODH | |
| SCHEMBL9870937 | 0.85 | GCGR (0.60) | GCGRSCN9ADHODH | |
| SCHEMBL8879993 | 0.84 | HMGCR (0.49) | GCGRFABP3FABP4FABP5DHODH | |
| SCHEMBL8878856 | 0.83 | GCGR (0.46) | GCGRFABP3FABP4FABP5 | |
| SCHEMBL8878474 | 0.83 | HMGCR (0.48) | GCGRFABP3FABP4FABP5DHODH | |
| SCHEMBL8878154 | 0.80 | DHODH (0.44) | GCGRFABP3FABP4FABP5DHODH | |
| SCHEMBL8949830 | 0.78 | GCGR (0.45) | GCGR | |
| SCHEMBL8877509 | 0.78 | MEN1 (0.49) | GCGRDHODH | |
| SCHEMBL8876808 | 0.78 | MEN1 (0.46) | FABP3FABP4FABP5DHODHPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| US-4997837-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4906624-A | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |