Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8877425 | 0.94 | HTR2C (0.41) | KDM4EHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL8890622 | 0.89 | GRM7 (0.40) | HTR2CDRD2HTR2AACHEGRM7 | |
| SCHEMBL2139852 | 0.83 | KDM4E (0.49) | KDM4EHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL9348192 | 0.74 | KDM4E (0.52) | KDM4EHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL5094876 | 0.73 | SLC6A2 (0.36) | PTGS2 | |
| SCHEMBL10448555 | 0.72 | KDM4E (0.45) | KDM4EHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL10450126 | 0.72 | KDM4E (0.45) | KDM4EHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL820846 | 0.72 | ACHE (0.42) | KDM4ECYP19A1ACHEPTGS2 | |
| SCHEMBL820213 | 0.72 | ACHE (0.42) | KDM4ECYP19A1ACHEPTGS2 | |
| SCHEMBL10388746 | 0.70 | KDM4E (0.57) | KDM4EHTR2CDRD2HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691322-A | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0444533-A2 | Quinoline and pyridine anchors for HMG-CoA reductase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |