Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | PI4KA | P42356 | 2/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.59 |
| ▸ | GAPDH | P04406 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20059210 | 1.00 | ADA (0.61) | ADAADORA3ADORA2AADORA2BPI4KA | |
| SCHEMBL13790712 | 1.00 | ADA (0.61) | ADAADORA3ADORA2AADORA2BPI4KA | |
| SCHEMBL12378913 | 0.89 | AHCY (0.53) | ADAADORA3ADORA2AADORA2BPI4KA | |
| SCHEMBL14064196 | 0.89 | AHCY (0.53) | ADAADORA3ADORA2AADORA2BPI4KA | |
| Deoxyadenosine SCHEMBL27603573 | 0.87 | HIF1A (0.72) | ADAADORA3ADORA2AADORA2BPI4KA | |
| Deoxyadenosine SCHEMBL23982174 | 0.87 | HIF1A (0.71) | ADAADORA3ADORA2AADORA2BPI4KA | |
| Deoxyadenosine SCHEMBL19877 | 0.87 | HIF1A (0.71) | ADAADORA3ADORA2AADORA2BPI4KA | |
| Deoxyadenosine SCHEMBL532825 | 0.87 | HIF1A (0.71) | ADAADORA3ADORA2AADORA2BPI4KA | |
| Deoxyadenosine SCHEMBL21637036 | 0.87 | HIF1A (0.71) | ADAADORA3ADORA2AADORA2BPI4KA | |
| SCHEMBL14565317 | 0.87 | ADA (0.62) | ADAADORA3ADORA2AADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066669-B2 | Oligonucleotides for modulating ATXN2 expression | HOFFMANN-LA ROCHE INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200024600-A1 | OLIGONUCLEOTIDES FOR MODULATING ATXN2 EXPRESSION | HOFFMANN-LA ROCHE INC. | 2020-01-23 | — | — | US | disclosed |
| US-7883869-B2 | for sequencing single-stranded DNA by employing a nanopore and modified nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-02-08 | — | — | US | disclosed |
| US-20100092952-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066669-B2 | Oligonucleotides for modulating ATXN2 expression | ATXN2, ATXN2L, ATXN10 | ADA 462/4885ADORA3 735/4885ADORA2A 854/4885 |
| US-20200024600-A1 | OLIGONUCLEOTIDES FOR MODULATING ATXN2 EXPRESSION | ATXN2, ATXN2L, ATXN10 | ADA 462/4885ADORA3 735/4885ADORA2A 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.