Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10459903 | 0.99 | CHRM2 (0.62) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL8879790 | 0.97 | CHRM2 (0.61) | CHRM2CHRM4CHRM1CYP1A2CHRM3 | |
| Hydrochloric Acid SCHEMBL9870848 | 0.96 | CHRM2 (0.60) | CHRM2CHRM4CHRM1CYP1A2CHRM3 | |
| SCHEMBL10519813 | 0.94 | CHRM2 (0.61) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL10513054 | 0.94 | CHRM2 (0.57) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL10515607 | 0.91 | CYP1A2 (0.51) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL10522160 | 0.91 | CYP1A2 (0.68) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL10515136 | 0.90 | CHRM2 (0.50) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL9870176 | 0.87 | CHRM2 (0.67) | CHRM2CHRM4CHRM1CYP1A2CYP3A4 | |
| SCHEMBL9870460 | 0.86 | CHRM2 (0.59) | CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346744-A1 | Condensed diazepinones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | claimed |
| US-5641772-A | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation | DR. KARL THOMAE GMBH (DE) | 1997-06-24 | — | — | US | disclosed |
| US-5610155-A | ALZHEIMER'S | DR. KARL THOMAE GMBH (DE) | 1997-03-11 | — | — | US | disclosed |
| EP-0508370-B1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | THOMAE GMBH DR K (DE) | 1996-07-03 | — | — | EP | disclosed |
| EP-0508370-A1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | Dr. Karl Thomae GmbH (DE) | 1992-10-14 | — | — | EP | disclosed |
| EP-0402734-A2 | Composition for the treatment of application of the central nervous system and to enhance cerebral perfusion | Dr. Karl Thomae GmbH (DE) | 1990-12-19 | — | — | EP | disclosed |
| EP-0346744-A1 | Condensed diazepinones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |