Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.60 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | THRA | P10827 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12670301 | 0.85 | SMN1; SMN2 (1.00) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 | |
| SCHEMBL8878947 | 0.82 | ALDH1A1 (0.59) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL11198289 | 0.82 | THRB (0.61) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL4455251 | 0.82 | ALDH1A1 (0.92) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 | |
| SCHEMBL991354 | 0.80 | ALDH1A1 (0.76) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 | |
| SCHEMBL4441360 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 | |
| SCHEMBL863522 | 0.80 | SMN1; SMN2 (0.81) | SMN1; SMN2GAAALDH1A1KDM4ETHRB | |
| SCHEMBL63569 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 | |
| SCHEMBL990939 | 0.79 | GAA (0.71) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 | |
| SCHEMBL3007594 | 0.79 | GAA (0.71) | SMN1; SMN2GAAALDH1A1KDM4EPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650541-A | Ethacrynic acid-like compounds and use thereof to treat glaucoma | ALCON LABORATORIES, INC. (US) | 1997-07-22 | — | — | US | claimed |