SCHEMBL887977

SCHEMBL887977

Nc1nc(N)c(NC=O)c(O)n1

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
ALDH1A1 P00352 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29903490 1.00 POLB (0.31) POLBMAPTKMT2AATMTDP1
Formic Acid SCHEMBL28960072 0.96
SCHEMBL1703076 0.90 ALDH1A1 (0.33) ALDH1A1CYP2C19
Water SCHEMBL8865234 0.83 ALDH1A1 (0.33) ALDH1A1CYP2C19
SCHEMBL774775 0.81
SCHEMBL6316984 0.78 CHUK (0.32) ALDH1A1CYP2C19
SCHEMBL8724985 0.77 ALDH1A1 (0.33) ALDH1A1CYP2C19
SCHEMBL22333830 0.72 DHFR (0.31)
SCHEMBL28385230 0.72 DHFR (0.37) POLBMAPTKMT2AATMTDP1
SCHEMBL28387294 0.72 CCNA2 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 323 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250369027-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS TWIST BIOSCIENCE CORP (US) 2025-12-04 US claimed
US-20250327068-A1 Method for Generation of a Nucleic Acid Library MILTENYI BIOTEC BV & CO KG (DE) 2025-10-23 US claimed
EP-4526441-A1 METHOD FOR GENERATION OF A NUCLEIC ACID LIBRARY Miltenyi Biotec B.V. & Co. KG (DE) 2025-03-26 EP claimed
EP-4504959-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS Twist Bioscience Corporation (US) 2025-02-12 EP claimed
US-12084715-B1 Methods and systems for reducing artifactual antisense products 10X GENOMICS, INC. (US) 2024-09-10 US claimed
US-20240117411-A1 METHODS FOR PREPARING CAPTURE SUBSTRATES ULTIMA GENOMICS INC (US) 2024-04-11 US claimed
WO-2023222713-A1 METHOD FOR GENERATION OF A NUCLEIC ACID LIBRARY Miltenyi Biotec B.V. & Co. KG (DE) 2023-11-23 WO claimed
EP-4279590-A1 METHOD FOR GENERATION OF A NUCLEIC ACID LIBRARY Miltenyi Biotec B.V. & Co. KG (DE) 2023-11-22 EP claimed
WO-2023196499-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS Twist Bioscience Corporation (US) 2023-10-12 WO claimed
CN-111646994-B Preparation method and application of 2, 4-diamino-6-hydroxy-5-formamido pyrimidine 潍坊奥通药业有限公司 2023-04-18 CN claimed
EP-0706581-A4 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOU (US) 1999-02-10 EP claimed
EP-0541003-B1 Process for the preparation of guanine and its alkali metal salts BOEHRINGER INGELHEIM PHARMA (DE) 1999-01-20 EP claimed
US-5665553-A Methods for determining and modulating cellular redox potential and genotoxic states PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1997-09-09 US claimed
US-5601981-A ASSAYING DNA FROM TEST SPECIMEN FOR CONCENTRATION OF RING-OPENED AND HYDROXYL DERIVATIVES, COMPARING, WHEREIN REDUCTIVE CELLULAR REDOX POTENTIAL EXISTS WHEN FORMATION OF RING-OPENED OVER HYDROXYL DERIVATIVES IS FAVORED PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1997-02-11 US claimed
EP-0706581-A1 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1996-04-17 EP claimed
WO-1994025626-A1 DNA PROFILES AS AN INDICATOR OF CELLULAR REDOX POTENTIAL AND CANCER RISK PACIFIC NORTHWEST RESEARCH FOUNDATION (US) 1994-11-10 WO claimed
EP-0541003-A2 Process for the preparation of guanine and its alcalnic metal salts BOEHRINGER INGELHEIM KG (DE) 1993-05-12 EP claimed
EP-0267594-B1 METHOD FOR THE CATALYTIC HYDROGENATION OF DAHNP AND FOR PREPARING DAFHP BOEHRINGER INGELHEIM KG (DE) 1993-02-10 EP claimed
US-4948890-A Process for the preparation of DAFNP BOEHRINGER INGELHEIM KG (DE) 1990-08-14 US claimed
EP-0267594-A1 Method for the catalytic hydrogenation of DAHNP and for preparing DAFHP BOEHRINGER INGELHEIM KG (DE) 1988-05-18 EP claimed