Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10861241 | 0.98 | SLC6A4 (0.50) | SLC6A4HDAC8SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL15218663 | 0.84 | KMT2A (0.50) | KDM4EPKMRECQLMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10508646 | 0.84 | ACACB (0.47) | SMN1; SMN2KDM4EALDH1A1TAAR1PKM | |
| SCHEMBL8734031 | 0.83 | SLC6A4 (0.57) | SLC6A4ALDH1A1TAAR1SLC6A2MEN1 | |
| SCHEMBL8734027 | 0.83 | SLC6A4 (0.57) | SLC6A4ALDH1A1TAAR1SLC6A2MEN1 | |
| SCHEMBL11253726 | 0.83 | SLC6A4 (0.57) | SLC6A4ALDH1A1TAAR1SLC6A2MEN1 | |
| SCHEMBL9812059 | 0.83 | SLC6A4 (0.56) | SLC6A4TAAR1SLC6A2MEN1KMT2A | |
| SCHEMBL9812052 | 0.83 | SLC6A4 (0.56) | SLC6A4TAAR1SLC6A2MEN1KMT2A | |
| SCHEMBL14944934 | 0.83 | SLC6A4 (0.56) | SLC6A4SMN1; SMN2ALDH1A1TAAR1 | |
| SCHEMBL9651945 | 0.83 | SLC6A4 (0.56) | SLC6A4SMN1; SMN2ALDH1A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| EP-0239815-A1 | Substituted thiazoles and oxazoles, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-10-07 | — | — | EP | disclosed |