⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328971 | 0.74 | TSHR (0.39) | — | |
| SCHEMBL1191251 | 0.73 | — | — | |
| SCHEMBL351330 | 0.73 | — | — | |
| SCHEMBL16955460 | 0.73 | — | — | |
| SCHEMBL350376 | 0.73 | — | — | |
| SCHEMBL351061 | 0.73 | — | — | |
| SCHEMBL979388 | 0.73 | — | — | |
| SCHEMBL16953010 | 0.70 | TSHR (0.31) | — | |
| SCHEMBL8880937 | 0.70 | CUL4A (0.31) | — | |
| SCHEMBL16955734 | 0.68 | APOBEC3G (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4209528-A | Antisecretory oxamic acid esters | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-06-24 | — | — | US | claimed |
| US-9145354-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2015-09-29 | — | — | US | disclosed |
| US-20150051199-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2015-02-19 | — | — | US | disclosed |
| CN-101389352-B | Agent for treating or preventing digestive ulcer | ASTELLAS PHARMA INC | 2012-09-19 | — | — | CN | disclosed |
| CN-101389352-A | Agent for treating or preventing digestive ulcer | ASTELLAS PHARMA INC (JP) | 2009-03-18 | — | — | CN | disclosed |
| CN-101282934-A | Triarylcarboxylic acid derivatives | ASTELLAS PHARMA INC (JP) | 2008-10-08 | — | — | CN | disclosed |
| US-5604225-A | DIETETICS; OBESITY | DR. KARL THOMAE GMBH (DE) | 1997-02-18 | — | — | US | disclosed |
| US-5457205-A | Substituted thiazoles useful for treatment of diabetes | DR. KARL THOMAE GMBH (DE) | 1995-10-10 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |
| US-4209528-A | Antisecretory oxamic acid esters | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-06-24 | — | — | US | disclosed |
| US-4137325-A | Antisecretory oxamic acid esters | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-01-30 | — | — | US | disclosed |