Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 4/20 | 0.44 |
| ▸ | CES1 | P23141 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704486 | 0.90 | MDM2 (0.61) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL3163300 | 0.88 | MDM2 (0.55) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL442090 | 0.88 | MDM2 (0.59) | MDM2LMNAHSD17B10PGRADRA2A | |
| Fluoride SCHEMBL28046161 | 0.86 | MDM2 (0.57) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL11876338 | 0.82 | MDM2 (0.53) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL4871573 | 0.82 | MDM2 (0.53) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL4871565 | 0.82 | MDM2 (0.53) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL5706319 | 0.82 | MDM2 (0.53) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL4871582 | 0.82 | MDM2 (0.53) | MDM2LMNAHSD17B10PGRADRA2A | |
| SCHEMBL17433562 | 0.81 | MDM2 (0.52) | MDM2LMNAHSD17B10PGRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691341-A | ANTILEUKEMIA AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5464833-A | Anticarcinogenic agents, antiretrovirus agents or autoimmune diseases | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-07 | — | — | US | disclosed |
| EP-0623598-A1 | APOPTOSIS REGULATOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-09 | — | — | EP | disclosed |