Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881872 | 0.90 | SMN1; SMN2 (0.39) | HPGDKMT2AMEN1KDM4ELMNA | |
| SCHEMBL8882636 | 0.89 | SMN1; SMN2 (0.39) | HPGDKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8882455 | 0.89 | PTPN1 (0.41) | KMT2AMEN1LMNASMN1; SMN2NPC1 | |
| SCHEMBL8882459 | 0.89 | IKBKB (0.39) | HPGDKMT2AMEN1IKBKBALDH1A1 | |
| SCHEMBL8882969 | 0.88 | PTPN1 (0.43) | KMT2AMEN1LMNASMN1; SMN2NPC1 | |
| SCHEMBL8884435 | 0.87 | TDP1 (0.42) | IKBKBTDP1KDM4ELMNAL3MBTL1 | |
| SCHEMBL8883715 | 0.86 | SMN1; SMN2 (0.37) | HPGDKMT2AIKBKBALDH1A1TDP1 | |
| SCHEMBL8881773 | 0.85 | HTT (0.40) | TDP1KDM4EGAAHTT | |
| SCHEMBL8882412 | 0.84 | MEN1 (0.47) | HPGDKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL8882517 | 0.83 | LNPEP (0.36) | HPGDIKBKBALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620995-A | Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |