Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 6/20 | 0.56 |
| ▸ | BCHE | P06276 | 4/20 | 0.56 |
| ▸ | BACE1 | P56817 | 4/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160636 | 0.90 | KDM4E (0.59) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL5671677 | 0.85 | KDM4E (0.70) | KDM4EGAAACHEBCHEBACE1 | |
| Hydrochloric Acid SCHEMBL11102409 | 0.84 | KDM4E (0.68) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL5112887 | 0.82 | ALDH1A1 (0.60) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL6819009 | 0.82 | KDM4E (0.61) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL8884292 | 0.80 | MAPK1 (0.77) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL3491711 | 0.79 | MEN1 (0.55) | KDM4EGAAACHEMCHR1MEN1 | |
| SCHEMBL10059770 | 0.79 | KDM4E (0.55) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL7173363 | 0.79 | KDM4E (0.46) | KDM4EGAAMEN1KMT2AMAPK1 | |
| SCHEMBL29525969 | 0.79 | KDM4E (0.46) | KDM4EGAAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067603-B2 | Opiod receptor-like receptors (ORL1); for treatment of chronic pain conditions, central nervous system disorders such as anxiety and stress disorders, depression, epilepsy, stroke, Alzheimer's disease, eating disorders, and drug abuse | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-11-29 | — | — | US | disclosed |
| US-8067603-B2 | Opiod receptor-like receptors (ORL1); for treatment of chronic pain conditions, central nervous system disorders such as anxiety and stress disorders, depression, epilepsy, stroke, Alzheimer's disease, eating disorders, and drug abuse | SOLVAY PHARMACEUTICALS B.V. (NL) | 2011-11-29 | — | — | US | disclosed |
| US-5661169-A | HAVE AFFINITY FOR VASOPRESSIN AND/OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1997-08-26 | — | — | US | disclosed |
| US-5585394-A | INHIBITOR, ANTAGONIST OF VASOPRESSIN OR OXYTOCIN | SANOFI (FR) | 1996-12-17 | — | — | US | disclosed |
| EP-0694536-A1 | 1-Benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-01-31 | — | — | EP | disclosed |
| EP-0636614-A1 | Derivatives of 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-02-01 | — | — | EP | disclosed |