Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 6/20 | 0.56 |
| ▸ | BCHE | P06276 | 4/20 | 0.56 |
| ▸ | BACE1 | P56817 | 4/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8883571 | 0.90 | KDM4E (0.59) | KDM4EGAAALDH1A1LMNAACHE | |
| SCHEMBL3291604 | 0.86 | KDM4E (0.64) | KDM4EGAAALDH1A1ACHEBCHE | |
| SCHEMBL5671677 | 0.85 | KDM4E (0.70) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL5112887 | 0.85 | ALDH1A1 (0.60) | KDM4EGAAALDH1A1LMNAACHE | |
| SCHEMBL6819009 | 0.84 | KDM4E (0.61) | KDM4EGAAALDH1A1LMNAACHE | |
| Hydrochloric Acid SCHEMBL11102409 | 0.84 | KDM4E (0.68) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL10059770 | 0.81 | KDM4E (0.55) | KDM4EGAAACHEBCHEBACE1 | |
| SCHEMBL3590004 | 0.81 | DRD2 (0.56) | KDM4EGAAALDH1A1LMNAACHE | |
| SCHEMBL6161561 | 0.80 | MAPK1 (0.80) | KDM4EGAAALDH1A1LMNAACHE | |
| SCHEMBL13419693 | 0.80 | KDM4E (0.74) | KDM4EGAAACHEBCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |