Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8883147 | 0.91 | HTT (0.39) | HTTEPHX2MAPK1XDHGALR3 | |
| SCHEMBL8883790 | 0.90 | AAK1 (0.39) | HTT | |
| SCHEMBL8883362 | 0.89 | IKBKB (0.38) | HTTMAPK1KDM4ECARM1PRMT6 | |
| SCHEMBL8882922 | 0.89 | IKBKB (0.38) | HTTMAPK1KDM4ECARM1PRMT6 | |
| SCHEMBL8882551 | 0.88 | LNPEP (0.36) | HTTKDM4ECARM1PRMT6 | |
| SCHEMBL8884848 | 0.88 | XIAP (0.42) | — | |
| SCHEMBL8882517 | 0.88 | LNPEP (0.36) | HTTKDM4ECARM1PRMT6 | |
| SCHEMBL8881873 | 0.88 | XIAP (0.42) | — | |
| SCHEMBL8883971 | 0.88 | CYP3A4 (0.35) | HTTXDH | |
| SCHEMBL8882669 | 0.87 | PTPN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620995-A | Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |