Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881773 | 0.88 | HTT (0.40) | GAAHTTTDP1XDH | |
| SCHEMBL8883058 | 0.86 | GRIN3B (0.38) | TP53TDP1 | |
| SCHEMBL8883715 | 0.86 | SMN1; SMN2 (0.37) | TP53NPC1GAASMN1; SMN2RAB9A | |
| SCHEMBL8883971 | 0.85 | CYP3A4 (0.35) | MAPTTP53NPC1GAAHTT | |
| SCHEMBL8884435 | 0.84 | TDP1 (0.42) | MAPTTP53NPC1HTTSMN1; SMN2 | |
| SCHEMBL8882459 | 0.84 | IKBKB (0.39) | MAPTNPC1GAAHTTSMN1; SMN2 | |
| SCHEMBL8883369 | 0.82 | HPGD (0.37) | NPC1GAAHTTSMN1; SMN2RAB9A | |
| SCHEMBL8881872 | 0.82 | SMN1; SMN2 (0.39) | MAPTGAAHTTSMN1; SMN2SMPD1 | |
| SCHEMBL8882455 | 0.81 | PTPN1 (0.41) | MAPTNPC1SMN1; SMN2SMPD1MEN1 | |
| SCHEMBL8779122 | 0.81 | MAPT (0.33) | MAPTTP53NPC1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5620995-A | Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-15 | — | — | US | disclosed |