Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NGFR | P08138 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8885156 | 0.81 | LMNA (0.36) | LMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11684908 | 0.71 | CA1 (0.48) | LMNAALDH1A1HPGDGAAL3MBTL1 | |
| SCHEMBL21130474 | 0.70 | LMNA (0.43) | LMNAALDH1A1HPGDGAAUSP2 | |
| SCHEMBL4495786 | 0.67 | LMNA (0.42) | LMNAALDH1A1HPGDGAARAB9A | |
| SCHEMBL9454972 | 0.66 | LMNA (0.53) | LMNAALDH1A1HPGDGAARAB9A | |
| SCHEMBL3184092 | 0.66 | LMNA (0.49) | LMNAALDH1A1HPGDGAAL3MBTL1 | |
| SCHEMBL19047336 | 0.65 | LMNA (0.41) | LMNAALDH1A1HPGDGAARAB9A | |
| SCHEMBL7290595 | 0.65 | NPSR1 (0.53) | LMNAALDH1A1GAARAB9AL3MBTL1 | |
| SCHEMBL1917991 | 0.65 | CYP1A2 (0.42) | ALDH1A1GAAL3MBTL1KDM4EHSD17B10 | |
| Formaldehyde SCHEMBL26124284 | 0.64 | HSD17B10 (0.61) | LMNAALDH1A1HPGDRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599823-A | HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-04 | — | — | US | disclosed |
| US-5356911-A | Hypotensive agents | BAYER AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| EP-0542059-A1 | Substituted biphenylpyridinones as angiotensin II antagonists | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |