Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884656 | 0.70 | LMNA (0.46) | LMNAUSP2ALDH1A1KDM4EHPGD | |
| SCHEMBL5028985 | 0.68 | CYP1A2 (0.54) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8513517 | 0.67 | CA12 (0.40) | LMNAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL1621957 | 0.64 | KDM4E (0.69) | LMNAALDH1A1KDM4EHPGDMEN1 | |
| Dacthal SCHEMBL53477 | 0.63 | CA12 (0.48) | LMNAALDH1A1KDM4EHPGDKMT2A | |
| Dacthal SCHEMBL8827292 | 0.63 | CA12 (0.48) | LMNAALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL9454972 | 0.62 | LMNA (0.53) | LMNAALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL3184092 | 0.62 | LMNA (0.49) | LMNAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL21130473 | 0.62 | USP2 (0.46) | LMNAUSP2ALDH1A1KDM4EHPGD | |
| SCHEMBL5334826 | 0.61 | CA12 (0.46) | LMNAALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019115776-A1 | SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2019-06-20 | — | — | WO | disclosed |