Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 16/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8883601 | 0.99 | TBXAS1 (0.65) | TBXAS1TBXA2RPOLBEPHX2MTNR1A | |
| SCHEMBL8885605 | 0.96 | TBXAS1 (0.64) | TBXAS1TBXA2RPOLBEPHX2MTNR1A | |
| SCHEMBL10444857 | 0.89 | TBXAS1 (0.53) | TBXAS1TBXA2RPOLBEPHX2MTNR1A | |
| SCHEMBL8882990 | 0.84 | TBXAS1 (0.75) | TBXAS1TBXA2R | |
| SCHEMBL8883469 | 0.82 | TBXAS1 (0.73) | TBXAS1TBXA2R | |
| SCHEMBL8882712 | 0.80 | TBXAS1 (0.83) | TBXAS1TBXA2R | |
| SCHEMBL8886110 | 0.79 | TBXAS1 (0.84) | TBXAS1TBXA2R | |
| SCHEMBL8885171 | 0.79 | TBXAS1 (0.67) | TBXAS1TBXA2REPHX2 | |
| SCHEMBL8775856 | 0.78 | TBXAS1 (0.82) | TBXAS1TBXA2REPHX2 | |
| SCHEMBL8775807 | 0.78 | TBXAS1 (0.82) | TBXAS1TBXA2REPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681961-A | TREATMENT AND/OR PREVENTION OF THROMBOEMBOLIC DISORDERS, ARTERIOSCLEROSIS, METASTASIS. ISCHEMIA, ASTHMA, ALLERGIES | DR. KARL THOMAE GMBH (DE) | 1997-10-28 | — | — | US | disclosed |
| EP-0397044-B1 | Arylsulfonamides, medicines containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1995-12-27 | — | — | EP | disclosed |
| US-5426119-A | Thromboxane antagonists | DR. KARL THOMAE GMBH (DE) | 1995-06-20 | — | — | US | disclosed |
| US-5294626-A | Thromboxane synthesis inhibitors and anticoagulants | DR. KARL THOMAS GMBH (DE) | 1994-03-15 | — | — | US | disclosed |
| EP-0397044-A2 | Arylsulfonamides, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-11-14 | — | — | EP | disclosed |