Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 0.78 |
| ▸ | HTR1D | P28221 | 18/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8864158 | 0.85 | HTR1A (0.95) | HTR1AHTR1DADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8864153 | 0.85 | HTR1A (0.95) | HTR1AHTR1DADRA1DADRA1AADRA1B | |
| SCHEMBL8880289 | 0.83 | HTR1A (0.74) | HTR1AHTR1D | |
| SCHEMBL8863907 | 0.81 | HTR1A (0.72) | HTR1AHTR1D | |
| SCHEMBL8885185 | 0.81 | HTR1A (0.75) | HTR1AHTR1DADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL8887313 | 0.80 | HTR1A (0.73) | HTR1AHTR1DADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9051868 | 0.79 | HTR1A (0.69) | HTR1AHTR1DADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9051866 | 0.79 | HTR1A (0.69) | HTR1AHTR1DADRA1DADRA1AADRA1B | |
| Oxalic Acid SCHEMBL8864004 | 0.79 | HTR1A (0.68) | HTR1AHTR1D | |
| Oxalic Acid SCHEMBL8864011 | 0.79 | HTR1A (0.68) | HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691344-A | Vasoconstrictive substituted dihydropyranopyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 1997-11-25 | — | — | US | claimed |
| EP-0714395-A1 | VASOCONSTRICTIVE SUBSTITUTED DIHYDROPYRANOPYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-06-05 | — | — | EP | claimed |
| WO-1995005381-A1 | VASOCONSTRICTIVE SUBSTITUTED DIHYDROPYRANOPYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-02-23 | — | — | WO | claimed |
| US-5691344-A | Vasoconstrictive substituted dihydropyranopyridines | JANSSEN PHARMACEUTICA, N.V. (BE) | 1997-11-25 | — | — | US | disclosed |
| EP-0714395-A1 | VASOCONSTRICTIVE SUBSTITUTED DIHYDROPYRANOPYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005381-A1 | VASOCONSTRICTIVE SUBSTITUTED DIHYDROPYRANOPYRIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-02-23 | — | — | WO | disclosed |