Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 4/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034411 | 0.84 | KDM4E (0.42) | ALDH1A1KDM4EGAAMEN1POLB | |
| SCHEMBL901473 | 0.78 | — | — | |
| SCHEMBL10175116 | 0.77 | — | — | |
| SCHEMBL8132166 | 0.70 | SLC6A2 (0.54) | ALDH1A1MEN1MAPTKMT2ACYP2C19 | |
| SCHEMBL19331285 | 0.69 | TYR (0.63) | KDM4ETYRDAO | |
| SCHEMBL1876155 | 0.69 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAMEN1POLB | |
| SCHEMBL11389129 | 0.68 | NPC1 (0.46) | ALDH1A1GAAMAPTKMT2ADAO | |
| SCHEMBL2735671 | 0.67 | — | — | |
| SCHEMBL11171888 | 0.67 | CYP1A2 (0.44) | ALDH1A1MEN1MAPTKMT2ADAO | |
| SCHEMBL358651 | 0.67 | IDH1 (0.57) | MEN1KMT2ATDP1DAOALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661146-A | ANALGESICS | G.D. SEARLE & CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5504077-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |
| WO-1995033733-A1 | SUBSTITUTED DIBENZOXAZEPINE AND DIBENZOTHIAZEPINE UREAS USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033734-A1 | SUBSTITUTED DIBENZOXAZEPINE AND DIBENZTHIAZEPINE CARBAMATES USEFUL AS PROSTAGLANDIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1995-12-14 | — | — | WO | disclosed |
| US-5449675-A | Analgesics | G. D. SEARLE & CO. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5441950-A | Analgesics, prostaglandin E2 antagonists | G. D. SEARLE & CO. (US) | 1995-08-15 | — | — | US | disclosed |