Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.59 |
| ▸ | NQO2 | P16083 | 7/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952490 | 0.84 | MTNR1A (0.75) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL7956065 | 0.83 | MTNR1A (0.73) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL7104353 | 0.82 | MTNR1A (0.86) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL7950130 | 0.82 | MTNR1A (0.86) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL10433963 | 0.81 | MTNR1A (0.58) | MTNR1AMTNR1BNQO2SIGMAR1TRPV1 | |
| SCHEMBL8887831 | 0.80 | MTNR1A (0.68) | MTNR1AMTNR1BNQO2TRPV1 | |
| SCHEMBL18898091 | 0.80 | SIGMAR1 (0.64) | MTNR1AMTNR1BNQO2SIGMAR1 | |
| SCHEMBL8572116 | 0.80 | SIGMAR1 (0.64) | MTNR1AMTNR1BNQO2SIGMAR1 | |
| SCHEMBL7952263 | 0.78 | MTNR1A (0.61) | MTNR1AMTNR1BNQO2SIGMAR1TRPV1 | |
| SCHEMBL14290815 | 0.78 | SIGMAR1 (0.64) | MTNR1AMTNR1BNQO2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661186-A | MELATONERGIC EFFECT; CENTRAL NERVOUS SYSTEM DISODERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-08-26 | — | — | US | claimed |
| EP-0728738-A1 | Tetralinyl- and indanyl-ethylamides having melatonergic activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-28 | — | — | EP | claimed |
| US-5661186-A | MELATONERGIC EFFECT; CENTRAL NERVOUS SYSTEM DISODERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0728738-A1 | Tetralinyl- and indanyl-ethylamides having melatonergic activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-08-28 | — | — | EP | disclosed |