Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10793933 | 0.84 | ACMSD (0.53) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL11862219 | 0.79 | ACMSD (0.47) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL18724371 | 0.79 | ACMSD (0.44) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL11857252 | 0.79 | ACMSD (0.44) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL1773230 | 0.78 | HTR2C (0.48) | ACMSDPTGS2HDAC1HDAC2HDAC3 | |
| SCHEMBL676296 | 0.78 | ACMSD (0.42) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL9343204 | 0.77 | HTR2C (0.47) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL9806363 | 0.76 | CALM1 (0.46) | ACMSDPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL18905499 | 0.76 | ACMSD (0.41) | ACMSDPTGS2KCNH2HRH3HDAC1 | |
| SCHEMBL625953 | 0.76 | MAOB (0.46) | ACMSDALDH1A1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5596020-A | Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5561143-A | ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5534532-A | ANTICHOLESTEROL AGENTS, SQUALENE SYNTHASE INHIBITOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5494918-A | ANTICHOLESTEROL AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5455260-A | Anticholesterol agents; reduction of serum cholesterol without reducing mevalonic metabolite synthesis; side effect | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5395846-A | Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5385912-A | Hypocholesterolemic or hypolipidemic agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-31 | — | — | US | disclosed |
| WO-1995000146-A1 | AMINO BI- AND TRI-CARBOCYCLIC ALKANE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| WO-1994027601-A1 | ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| WO-1992015579-A1 | MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-17 | — | — | WO | disclosed |