Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884921 | 0.84 | KDM4E (0.48) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| SCHEMBL8885954 | 0.81 | WHR1 (0.50) | WHR1L3MBTL1PDGFRBPDGFRAMAPT | |
| SCHEMBL7819852 | 0.81 | WHR1 (0.48) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| SCHEMBL8884725 | 0.80 | WHR1 (0.41) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| SCHEMBL7825968 | 0.79 | WHR1 (0.46) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| SCHEMBL7820197 | 0.79 | PDE4A (0.48) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| SCHEMBL7818387 | 0.78 | MAPT (0.46) | WHR1PDE4APDE4DL3MBTL1PDE3B | |
| SCHEMBL8886056 | 0.77 | WHR1 (0.44) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| Diethylamine SCHEMBL8136070 | 0.75 | PDE4A (0.56) | WHR1PDE4APDE4DL3MBTL1PDGFRB | |
| SCHEMBL8138601 | 0.75 | WHR1 (0.42) | WHR1PDE4APDE4DL3MBTL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650410-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0749426-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024394-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-09-14 | — | — | WO | disclosed |