Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | WHR1 | P49842 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8123003 | 0.88 | TSHR (0.46) | MAPTLMNADHODHL3MBTL1ACHE | |
| SCHEMBL9181338 | 0.82 | SLC10A2 (0.47) | MAPTLMNAADORA3DCTPP1ALDH1A1 | |
| SCHEMBL7820197 | 0.81 | PDE4A (0.48) | MAPTLMNAWHR1PDE4APDE4D | |
| SCHEMBL7819852 | 0.81 | WHR1 (0.48) | MAPTWHR1PDE4APDE4DL3MBTL1 | |
| SCHEMBL8884921 | 0.79 | KDM4E (0.48) | MAPTWHR1ADORA3PDE4APDE4D | |
| SCHEMBL7825968 | 0.79 | WHR1 (0.46) | MAPTWHR1PDE4APDE4DL3MBTL1 | |
| SCHEMBL8886069 | 0.78 | WHR1 (0.43) | MAPTWHR1PDE4APDE4DL3MBTL1 | |
| SCHEMBL8131460 | 0.76 | PDE4A (0.42) | MAPTLMNAWHR1PDE4APDE4D | |
| SCHEMBL8885954 | 0.76 | WHR1 (0.50) | MAPTWHR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8884725 | 0.75 | WHR1 (0.41) | MAPTWHR1PDE4APDE4DL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608870-B1 | Quinoline or quinazoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0634169-B1 | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-5932592-A | ETHYL 4-(3,4-DIMETHOXYPHENYL)-6,7-DIMETHOXY-2-(1,2,4-TRIAZOLE-1-YLME THYL)QUINOLINE-3-CARBOXYLATE; ANTIINFLAMMATORY AND ANTIARTHRITIC AGENT | TAKEDA CHEMICAL IND., LTD. (JP) | 1999-08-03 | — | — | US | disclosed |
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5770602-A | REACTING QUIONOZOLINE OR QUINOLINE DERIVATIVES CONTAINING LEAVING GROUPS WITH NITROGEN CONTAINING UNSATURATED CYCLIC GROUP WHICH MAY BE SUBSTITUTED OR UNSUBSTITUTED; ANTIARTHRITIC AGENT | TAKEDA CHEMICAL INDUSTRIES (JP) | 1998-06-23 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5650410-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0749426-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024394-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-09-14 | — | — | WO | disclosed |
| US-5436247-A | Antiinflammatory agents or antiarthritic agents | TAKEDA CHEMICAL INDUSTRIES (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0634169-A1 | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-18 | — | — | EP | disclosed |
| EP-0608870-A1 | Quinoline or quinazoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-03 | — | — | EP | disclosed |