Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.32 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560752 | 0.83 | MAPK1 (0.52) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28962436 | 0.80 | MAPK1 (0.55) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL29236914 | 0.80 | MEN1 (0.49) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8883110 | 0.79 | MAPK1 (0.47) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28071724 | 0.73 | MAPK1 (0.53) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8886141 | 0.72 | MAPK1 (0.41) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL22338446 | 0.72 | MAPK1 (0.41) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL31682254 | 0.71 | MAPK1 (0.61) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3713042 | 0.71 | MAPK1 (0.61) | MAPK1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL27435879 | 0.71 | CES1 (0.39) | MAPK1ALDH1A1CES1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650410-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0749426-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1996-12-27 | — | — | EP | disclosed |
| WO-1995024394-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS, IN PARTICULAR FOR TREATING ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-09-14 | — | — | WO | disclosed |