Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886068 | 0.91 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL9185327 | 0.86 | ITGB3 (0.38) | PRSS1PRSS2PRSS3TSHRITGB3 | |
| SCHEMBL8887118 | 0.83 | USP30 (0.44) | PRSS1PRSS2PRSS3ITGB3ITGA2B | |
| SCHEMBL9094547 | 0.83 | USP30 (0.44) | PRSS1PRSS2PRSS3ITGB3ITGA2B | |
| SCHEMBL8410563 | 0.80 | KDM1A (0.48) | PDE4BPRSS1PRSS2PRSS3F2 | |
| SCHEMBL8885229 | 0.80 | F2 (0.40) | PRSS1PRSS2PRSS3F2F10 | |
| SCHEMBL8949055 | 0.77 | ITGB3 (0.38) | PRSS1PRSS2PRSS3TSHRNEK2 | |
| SCHEMBL8949064 | 0.77 | ITGB3 (0.38) | PRSS1PRSS2PRSS3TSHRNEK2 | |
| SCHEMBL8949416 | 0.75 | ITGB3 (0.39) | PRSS1PRSS2PRSS3ITGB3ITGA2B | |
| SCHEMBL8949414 | 0.75 | ITGB3 (0.39) | PRSS1PRSS2PRSS3ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |