Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.40 |
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | PLAT | P00750 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | TMPRSS15 | P98073 | 4/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.36 |
| ▸ | FASN | P49327 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886068 | 0.89 | PDE4A (0.40) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL9185327 | 0.89 | ITGB3 (0.38) | F2F10PLAUPLATPRSS1 | |
| Hydrochloric Acid SCHEMBL8887529 | 0.86 | F2 (0.45) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL8887677 | 0.84 | F2 (0.37) | F2PRSS1PLGMELK | |
| SCHEMBL8885472 | 0.82 | EGLN1 (0.38) | MELKFASN | |
| SCHEMBL8407959 | 0.81 | F2 (0.48) | F2F10PLAUPLATPRSS1 | |
| Hydrochloric Acid SCHEMBL8949125 | 0.80 | F2 (0.37) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL8886191 | 0.80 | PDE4A (0.41) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL8949363 | 0.79 | TMPRSS15 (0.43) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL8949356 | 0.79 | TMPRSS15 (0.43) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |