Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886471 | 1.00 | FGFR1 (0.42) | FGFR1FGFR2CYP19A1CYP11B2KDM4E | |
| SCHEMBL11013839 | 1.00 | FGFR1 (0.42) | FGFR1FGFR2CYP19A1CYP11B2KDM4E | |
| SCHEMBL2795793 | 0.83 | HTT (0.35) | FGFR1FGFR2HPGDALDH1A1MEN1 | |
| SCHEMBL2795794 | 0.83 | HTT (0.35) | FGFR1FGFR2HPGDALDH1A1MEN1 | |
| SCHEMBL12609484 | 0.76 | KDM4E (0.42) | FGFR1FGFR2CYP19A1CYP11B2KDM4E | |
| SCHEMBL25248267 | 0.74 | NOTUM (0.40) | CYP19A1CYP11B2HPGDALDH1A1MEN1 | |
| SCHEMBL782667 | 0.74 | NOTUM (0.40) | CYP19A1CYP11B2HPGDALDH1A1MEN1 | |
| SCHEMBL782668 | 0.74 | NOTUM (0.40) | CYP19A1CYP11B2HPGDALDH1A1MEN1 | |
| SCHEMBL7480796 | 0.74 | ALDH1A1 (0.45) | HPGDALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7480793 | 0.74 | ALDH1A1 (0.45) | HPGDALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639766-A | TREATING CENTRAL NERVOUS SYSTEM AILMENTS RELATED TO GAMMA-AMINOBUTYRIC ACID UPTAKE | NOVO NORDISK A/S (DK) | 1997-06-17 | — | — | US | disclosed |
| EP-0707568-A1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF | NOVO NORDISK A/S (DK) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995000484-A1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF | NOVO NORDISK A/S (DK) | 1995-01-05 | — | — | WO | disclosed |
| US-4548946-A | Antiinflammatory and/or analgesic 1,8-Dihydro-(or 3,8-dihydro)-8-aryl-2-[(substituted)thio]-indeno[1,2-d]imidazoles and their corresponding sulfoxides and sulfones | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-10-22 | — | — | US | disclosed |
| EP-0061712-A1 | Antiinflammatory and/or analgesic 1,8-dihydro (or 3,8-dihydro)-8-aryl-2-((substituted)thio)-indeno(1,2-)imidazoles and their corresponding sulfoxides and sulfones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-10-06 | — | — | EP | disclosed |