Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327382 | 0.79 | KDM4E (0.49) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2737262 | 0.77 | KDM4E (0.49) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8887353 | 0.77 | IDO1 (0.38) | TSHRMEN1KMT2ATP53CYP3A4 | |
| SCHEMBL20314712 | 0.76 | KDM4E (0.49) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8886475 | 0.76 | KDM4E (0.46) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8886480 | 0.76 | KDM4E (0.46) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28639522 | 0.76 | SMN1; SMN2 (0.56) | KDM4ETSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL25331886 | 0.75 | SLC6A4 (0.39) | KDM4ETSHRALDH1A1LMNAPPARG | |
| SCHEMBL3468664 | 0.75 | SLC6A4 (0.39) | KDM4ETSHRALDH1A1LMNAPPARG | |
| SCHEMBL9064396 | 0.75 | PPARG (0.51) | KDM4EALOX5PPARGPPARATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |